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BRL 37344 sodium
CAS No. 127299-93-8
BRL 37344 sodium( BRL37344 sodium )
Catalog No. M11141 CAS No. 127299-93-8
BRL 37344 is a potent and selective β3 adrenoceptor agonist with Ki of 287 nM; has weaker binding affinity for β1 and β2 receptors with Ki of 1750 and 1120 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 685 | Get Quote |
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| 100MG | 1035 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBRL 37344 sodium
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NoteResearch use only, not for human use.
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Brief DescriptionBRL 37344 is a potent and selective β3 adrenoceptor agonist with Ki of 287 nM; has weaker binding affinity for β1 and β2 receptors with Ki of 1750 and 1120 nM, respectively.
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DescriptionBRL 37344 is a potent and selective β3 adrenoceptor agonist with Ki of 287 nM; has weaker binding affinity for β1 and β2 receptors with Ki of 1750 and 1120 nM, respectively; A potent agonist in brown adipocytes (EC50 = 3.3 +/- 0.8 nM) than in white adipocytes (EC50=5.7 nM) or colon (EC50=27.5 nM); Stimulates fuel oxidation by soleus muscle in vitro.Diabetes Discontinued.
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In Vitro——
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In VivoBRL37344 sodium (BRL 37344A) treatment significantly lowers the body weight of obese mice. Animal Model:Five-week-old male Imprinting Control Region (ICR) mice Dosage:2.5 mg/kg Administration:Intraperitoneal injection; three times per week for two weeks Result:Lowered the body weight of obese mice.
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SynonymsBRL37344 sodium
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PathwayGPCR/G Protein
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number127299-93-8
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Formula Weight385.82
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Molecular FormulaC19H21NO4ClNa
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (12.96 mM加)
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SMILESCC(CC1=CC=C(C=C1)OCC(=O)[O-])NCC(C2=CC(=CC=C2)Cl)O.[Na+]
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Chemical NameRel-2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-acetic acid, monosodium salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Arch JR, et al. Nature. 1984 May 10-16;309(5964):163-5.
2. Oriowo MA, et al. J Pharmacol Exp Ther. 1996 Apr;277(1):22-7.
3. Board M, et al. Eur J Pharmacol. 2000 Oct 6;406(1):33-40.
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