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Home - Products - Angiogenesis - Adrenergic Receptor - BRL 37344 sodium

BRL 37344 sodium

CAS No. 127299-93-8

BRL 37344 sodium ( BRL37344 sodium )

Catalog No. M11141 CAS No. 127299-93-8

BRL 37344 is a potent and selective β3 adrenoceptor agonist with Ki of 287 nM; has weaker binding affinity for β1 and β2 receptors with Ki of 1750 and 1120 nM, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BRL 37344 sodium
  • Note
    Research use only, not for human use.
  • Brief Description
    BRL 37344 is a potent and selective β3 adrenoceptor agonist with Ki of 287 nM; has weaker binding affinity for β1 and β2 receptors with Ki of 1750 and 1120 nM, respectively.
  • Description
    BRL 37344 is a potent and selective β3 adrenoceptor agonist with Ki of 287 nM; has weaker binding affinity for β1 and β2 receptors with Ki of 1750 and 1120 nM, respectively; A potent agonist in brown adipocytes (EC50 = 3.3 +/- 0.8 nM) than in white adipocytes (EC50=5.7 nM) or colon (EC50=27.5 nM); Stimulates fuel oxidation by soleus muscle in vitro.Diabetes Discontinued
  • Synonyms
    BRL37344 sodium
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    Adrenergic Receptor
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    127299-93-8
  • Formula Weight
    385.82
  • Molecular Formula
    C19H21NO4ClNa
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(CC1=CC=C(C=C1)OCC(=O)[O-])NCC(C2=CC(=CC=C2)Cl)O.[Na+]
  • Chemical Name
    Rel-2-[4-[(2S)-2-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]-acetic acid, monosodium salt

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Arch JR, et al. Nature. 1984 May 10-16;309(5964):163-5.
2. Oriowo MA, et al. J Pharmacol Exp Ther. 1996 Apr;277(1):22-7.
3. Board M, et al. Eur J Pharmacol. 2000 Oct 6;406(1):33-40.
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